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Carmustine (bis-chloroethylnitrosourea, BCNU, BiCNU) is a medication acclimated to foremost in regard to chemotherapy. It is a nitrogen mustard ß-chloro-nitrosourea amalgam used as an alkylating agent.

Carmustine is used as an alkylating agent to usage of distinct types of percipience cancer including glioma, glioblastoma multiforme, medulloblastoma and astrocytoma), multiple myeloma, and lymphoma (Hodgkin's and non-Hodgkin).

BCNU is sometimes used in conjunction with alkyl guanine transferase (AGT) inhibitors, such as O6-benzylguanine. The AGT-inhibitors spread the efficacy of carmustine by inhibiting the direct u-turn pathway of DNA repair, which at one's desire abort accumulation of the interstrand crosslink between the N1 of guanine and the N3 of cytosine.

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